Antifungal properties of primine a benzoquinone isolated from Miconia affinis (Melastomataceae) and synthetic analogues actino against human opportunistic and soybean infecting fungi.

DERITA, M. G.; SVETAZ, L.; CALDERÓN, A.; SOLÍS, P.; GUPTA, M.; HERRERA, A.; COY, R.; PEREZ, A; ZACCHINO, S. A.

Sao Pedro

Simposio; 2nd Internacional Joint Symposium: Chemistry, Biological and Pharmacological Properties of Medicinal Plants From The Americas; 2004

The antifungal 3-pentyl-5-methoxy-1,4-benzoquinone (primine) has been isolated from the methanolic extract of the Panamanian plan Miconia affinis D.C. Since some quinine analogues including 1,4-benzoquinones and 1,2- and 1,4-naphtoquinones1 have shown interesting antifungal properties against phytopathogenic as well opportunistic human fungi,2 we tested a series of 1,4-naphtoquinones against a panel of yeast, hialohyphomycetes as well as dermatophytes and 13 isolated strains of soybean pathogenic fungi, belonging to 6 genera and 7 species. The most susceptible species were Colletotrichumn truncatum and Phomopsis longicola, which are the causes of the most serious soybean diseases due to their high incidence and persistence.