INVESTIGADORES
DERITA Marcos Gabriel
artículos
Título:
Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
Autor/es:
DERITA, M.; DEL OLMO, E.; BARBOZA, B.; GARCÍA-CADENAS, A; LÓPEZ-PÉREZ, J.; ANDÚJAR, S.; ENRIZ, D.; ZACCHINO, S.; SAN FELICIANO, A.
Revista:
MOLECULES
Editorial:
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
Referencias:
Lugar: Basel; Año: 2013 vol. 18 p. 3479 - 3501
ISSN:
1420-3049
Resumen:
Abstract: Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as well as against some clinical isolates. A physicochemical study performed on compound 5 revealed its conformational and electronic characteristics, providing us with useful data for the future design of novel related antifungal analogues.
