Value of the ethnomedical information for the discovery of plants with antifungal properties. A survey among seven Latin American countries.

SVETAZ, L.; ZULJAN, F.; DERITA, M.; PETENATTI, E.; TAMAYO, G.; CÁCERES, A.; CECHINEL FILHO, V.; GIMENEZ, A.; PINZÓN, R.; ZACCHINO, S.; GUPTA, M.

JOURNAL OF ETHNOPHARMACOLOGY

ELSEVIER IRELAND LTD

Año: 2010 vol. 127 p. 137 - 158

0378-8741

This study reports the antifungal evaluation of 327 plant species (92 families and 251 genera) from seven Latin American countries which were selected on the basis of their reported ethnomedical uses and compared them with plants selected at random. (a) The main aim of this study was to investigate whether the probability of detecting antifungal plants is higher when plants have reports of ethnopharmacological uses related to fungal infections (PAU group) than when they are selected at random (PNAU group). (b) The second objective was to determine, within the PAU group, whether the probability of obtaining a positive result will be higher when the plants are tested against dermatophytes, than against yeasts or Aspergillus spp. (c) The third goal was to investigate, within all MICs lower than 1000 ug/mL, if the MICs displayed by the PAU group are comparatively lower than MIC values of the PNAU group; that is to say, if they can be expected more potent antifungal plants within the group of plants that have a history of traditional use related to fungal infections than when they do not have one. Results: (a) A significantly higher probability of detecting plants with antifungal activity against at least one fungus was found within the PAU (40.3%) than the PNAU group (21.3%) (p < 0.01). (b) A similar higher probability than in (a) (39.6% vs. 20.8%) was found when plants were tested against dermatophytes (p < 0.01) but not against yeasts or Aspergillus spp. (p > 0.05). (c) Within the detected antifungal plants from both groups, plants of the PAU group displayed higher activities (lower MICs) than those of PNAU group against dermatophytes (p < 0.05) but not against yeasts or Aspergillus spp. Conclusions: Considering that dermatophytes are the cause of superficial fungal infections, which can be easily detected and followed by traditional healers, our findings suggest that the ethnopharmacological approach is useful in guiding the detection of antifungal plants in Latin America mainly for infections in which the pathological expression is obvious and, therefore, the cure can be clearly observed.