ALTERACIONES EN EL DESARROLLO PRENATAL DE RATAS TRATADAS CON DIFERENTES COMPOSICIONES PROTEICAS E INTOXICADAS CON CADMIO

BIAGGIO VS; ALTAMIRANO KN; GIMENEZ MS

Congreso; SOCIEDAD DE BIOLOGIA DE CUYO; 2013

Prenatal stress affects the developing fetus with possible loss of neurons and cognitive function and alterations in several tissues. Intoxication with cadmium (Cd) causes an imbalance between anti- and pro-oxidant mechanisms. We evaluate the possible protective role of soy protein consumption against the mechanisms by which Cd exerts its toxicity. Four lots of female Wistar rats were used: 2 lots received casein (Cas) and 2 lots Soy as protein source. Within each group, 1 lot received regular water (control-Co) and the other, 15 ppm of Cd in the drinking water during pregnancy period. We determined nitrites and lipid peroxidation in fetal tissue and CAT (Catalase) and GPx (Glutathione peroxidase) activities. The body weights of pups and adult rats, was measured. In brain, CAT activity increased in the Cas-Cd group (p