ANGIOTENSIN II AT-2 RECEPTOR mRNA IS INCREASED BY HYPOXIC-PRECONDITIONING (HP) IN THE BRAIN AND CEREBELLUM OF THE NEONATAL RAT

FRANCISCO LÓPEZ AGUILERA, VERÓNICA BIAGGIO, ALICIA SELTZER.

Córdoba-Huerta Grande

Congreso; CONGRESO ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACION EN NEUROCIENCIAS; 2010

CONGRESO ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACION EN NEUROCIENCIAS

Angiotensin II, an octapeptide compromised with mechanisms of organ injury and repair acts through the membrane receptors AT1-R and AT2-R. In previous experiments we observed a transient increase of AT2-R protein in the brain of HP animals. We examined by RT-PCR the temporal expression of the AT2-R mRNA in the brain and cerebellum of rat pups after being submitted to Hypoxia-Ischemia (HI) on day8 after birth and treated with HP 24h before injury . On Day 1 after HI the HP group showed a significant decrease of the transcript (p