ANGIOTENSINA II Y LA PREÑEZ HIPERTENSA

BIAGGIO VS, LÓPEZ AGUILERA F, SELTZER AM.

Mendoza- Ciudad

Congreso; SOCIEDAD DE BIOLOGIA DE CUYO (SOBIO); 2010

SOCIEDAD DE BIOLOGIA DE CUYO (SOBIO)

Hypertension during pregnancy and placental vascular insufficiency are common conditions that affect the development of the fetus. The offspring of spontaneously hypertensive (SHR) rats during uterine life suffer vascular aberrations that increase their mortality rate and delay the maturation of the nervous system. The members of the renin-angiotensin system (RAS) are present in the brain, cerebellum and placenta of pregnant females and angiotensin II and its cell membrane receptors AT1 and AT2 are known to play a role in the vascular events that occur during the adaptive response to high blood pressure. In addition we propose their participation in the remarkable spontaneous recovery of neurological and behavioral defects that show the surviving pups. We demonstrated significant differences between WKY and SHR during development: Body weight: (***) p