EFECTOS DE LA CASTRACION Y LA RESTITUCION CON TESTOSTERONA SOBRE LA HISTOARQUITECTURA DEL PULMON

PÉREZ CHACA MV, BIAGGIO VS, CABALLERO N, GARAY PG, VINCENT A, FORNES M, GIMÉNEZ MS, GÓMEZ NN.

Ciudad de La Punta- San Luis - Capital

Congreso; SOCIEDAD de BIOLOGIA DE CUYO (SBC); 2009

SOCIEDAD de BIOLOGIA DE CUYO (SBC)

There is strong evidence that oxidative stress plays a key role in the pathophysiology of several lung diseases. The presence of specific androgens and estrogens receptors in the lung implies that sex hormones play a physiological role in pulmonary function. The present study was designed to determine whether castration and androgen replacement result in changes in the lung histoarchitecture. Wistar male rats (200± 20 g) were separated in three groups: controls (Co, n:6), castrated (Ca, n:6), and castrated replaced with testosterone (Ca+T, n:6), 60 days after castrations. The lungs were processed for light microscopy, image analysis system (ImageJ) was used and oxidative stress biomarkers were measured. ANOVA was used for statistical analysis. The results indicate that castration significantly affected the antioxidant status, its evidenced by a significant increase lipid peroxidation in serum TBAR’S (mM/mg protein), Co: 0.7± 0,0003 and Ca: 1,6±0,0009 (p