Relación entre niveles de selenio en sangre y diferentes patologías prostáticas

LÓPEZ FONTANA CM, ; PÉREZ ELIZALDE R; VANRELL C; RECALDE G; UVILLA A; LÓPEZ LAUR JD

ACTAS UROLOGICAS ESPANOLAS

ENE EDICIONES SL

Lugar: MADRID ESPAÑA; Año: 2010 vol. 34 p. 625 - 629

0210-4806

Several studies have demonstrated an inverse relation between serum selenium levels (Se) and advanced prostate cancer (PCa). OBJECTIVE: To determine and compare selenium plasma levels in patients with different prostatic pathologies. MATERIAL AND METHODS: It is a transversal, descriptive and comparative study. A sample of 64 men between 50 and 80 years old were selected for the study between 2007 and 2009. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy (12-14 chips). Prostate cancer was subclassified according to Gleason Score. Selenium was determined indirectly by serum Glutathione peroxidase (Kit Ransel, Randox SRL, Crumlin, UK). Statistical analysis was performed using ANOVA I (p<0.05). RESULTS: Glutathione Peroxidase level was 33.75+/-2.36 mg/ml in control patients. A decrease of 31.6% was observed in patients with BPH (23.08+/-1.57 mg/ml) and of (63.6%) in subjects with prostate cancer (12.28+/-1.03 mg/ml) (p<0,0001). There was no correlation with the Gleason Score. CONCLUSION: Serum Seleniun is lower in patients with prostatic pathologies being even more important in cancer patients regardless the Gleason Score.