Lipoteichoic acid challenge induces higher inflammatory responses than lipopolysaccharide in UV irradiated keratinocytes

ELIANA M. CELA; FEDERICO S. WEILL; MARIELA L. PAZ; JULIANA LEONI; DANIEL H. GONZALEZ MAGLIO

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2015 vol. 31 p. 111 - 114

0905-4383

Keratinocytes are the main cell population of the epidermis and play a crucial role in the maintenance of skin homeostasis. Keratinocytes are in constant dialog with skin commensal bacteria (mostly gram-positive) to prevent pathogen invasion. Solar ultraviolet radiation impacts on skin and produces changes in the integrity of the epithelia, allowing commensal bacteria to reach the dermis and trigger an inflammatory response. We aimed to compare the antimicrobial response of UV irradiated keratinocytes exposed to lipoteichoic acid and lipopolysaccharide by the production of proinflammatory cytokines, IL-6 and TNF-α, and the role of Vitamin D pathway in this model. Surprisingly, keratinocytes response after UV exposure was more intense to lipoteichoic than to lipopolysaccharide, indicating that the disrupted epithelium reacts to commensal bacteria to avoid potential infections.