Transcriptomic analysis and molecular docking reveal genes involved in the response of Aedes aegypti larvae to an intoxication with a natural essential oil extracted from Eucalyptus

IVANA SIERRA; JOSE MANUEL LATORRE ESTIVALIS; LUCILA TRAVERSO; GONZALEZ, PAULA V; ARIEL APTEKMANN; ALEJANDRO NADRA; HECTOR MASUH; SHEILA ONS

PLOS NEGLECTED TROPICAL DISEASES

PUBLIC LIBRARY SCIENCE

Año: 2021

1935-2735

Aedes aegypti (L.) is an urban mosquito, vector of several arboviruses that causesevere diseases in hundreds of million people each year. The resistance to neurotoxicinsecticides developed by Ae. aegypti populations worldwide has contributed to failures invector control campaigns, increasing the impact of arbovirus diseases. Moreover, neurotoxicshave a high environmental impact due to their low biodegradability and deleterious effectsin non-target species, among other reasons. In this context, plant-derived essential oils withlarvicidal activity could be an attractive alternative for vector control. However, the mode ofaction and the detoxificant response of mosquitoes to plant derived compounds have notbeen established, impairing the optimization of their use.