RELATIVE BIOAVALABILITY OF COENZYME Q10 FORMULATIONS FOR PEDIATRIC INDIVIDUALIZED THERAPY: PRELIMINARY STUDY

MARTINEFSKI MANUELA; SAMASSA PAULA; CONTIN MARIO; LUCANGIOLI SILVIA; BUONTEMPO FABIAN; TRIPODI VALERIA

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2013 p. 79 - 80

0928-0987

Coenzyme Q10 (CoQ10) deficiency is involved in degenerative muscle and neuronal diseases which have shown clinical improvement with oral CoQ10 supplementation specially if it is started during childhood. The administration of drugs in pediatrics is a unique challenge and requires individualized therapy. Liquid formulations rather than solid dosage forms are preferred for oral administration to children specially in those with difficulty swallowing. In order to increase the bioavailability of CoQ10, facilitate its administration in pediatrics and therefore increase the therapeutic efficacy, we have previously developed an oil-in-water (O/W) liquid emulsion of CoQ10 with proved stability and safe when narrow dose adjustment is required (1). The objective of this work is to establish the relative bioavailability of this new developed liquid formulation in comparison to the solid CoQ10 form administered at low and high doses.