Dynamic scale-dependent mo- dulation of behavioral patterns induced by caloric or temporal feed restriction

PAULA SOFIA NIETO; A.G. FLESIA; JACKELYN KEMBRO

Conferencia; Animal Behaviour Live: Annual Online Conference 2021; 2021

The temporal dynamics of behavior is complex because it reflects processesoccurring at different temporal scales, susceptible to modulation by externalfactors. For example, locomotor activity in mammals presents circadianrhythms and other dynamics (i.e. other rhythms and long-range -“fractal”-auto-correlation), which in turn are differentially affected by external cues (i.e:feeding schedules). Identifying changes in such behavioral patterns isimportant to understand behavioral adaptation to the environment, yet thereare no clear tools to characterize and quantify them. Herein, we analyzebehavioral time series derived from mice exposed to different feedingparadigms (i.e: temporal or caloric restriction, TR or CR respectively). Weevaluate the dynamic changes of feeding and wheel-running behaviorthroughout a 42-day experiment. Specifically, we applied a 5-step waveletapproach to detect and characterize behavioral rhythms and detrendedfluctuation analysis (DFA) to assess changes in auto-correlation properties atsmaller scales. We found that the feeding paradigm imposed to micedifferentially modulates the acrophase and strength (power) of circadianrhythms in both running wheel and feed intake activity. TR and CR paradigmsduring daytime induce circadian rhythm weakness in feed intake, consistentwith a transitional state in which the phase of these rhythms abruptly changesfollowing the food onset. We detect ultradian rhythms in feed-intake and wheelrunning time series and their robustness depends on the behavior studied,feeding paradigm and individual differences. Long-range correlations wereobserved in the wheel-running, but not in feed-intake for scales