Synaptic composition and protein acetylation change during Inhibitory avoidance Consolidation in mice

BUSSO MJ; BOCCIA MM; BLAKE MG; SALLES A; FREUDENTHAL R

Mar del Plata

Congreso; XXX Annual Meeting and SAN-ISSN small conference and course; 2015

SAN - Sociedad Argentina de Investigación en Neurociencias

It is well known that synapses are plastic structures involved in processes such synaptic plasticity and memory consolidation. Previous studies show that protein composition of the synapse changes during memory consolidation. There is evidence that synaptic protein composition is, at least partly, modulated by Post-Translational modifications (PTM). Furthermore synaptic plasticity and memory consolidation rely in many cases on these PTM of the proteins composing the synapse. In particular, some of the changes that occur at the synapse during these processes involve a reorganization and protein redistribution. Here we use the inhibitory avoidance learning task in mice to study a particular type of PTM, the lysine acetylation, during memory consolidation. We evaluate the changes in synaptic protein composition that occur after training, in correlation with changes in protein acetylation.