Vanadium Effects on Bone Metabolism

ETCHEVERRY SB; DIVIRGILIO AV; BARRIO DA

Vanadium: Biochemical and Molecular Biological Approaches.

Springer

Lugar: Berlin; Año: 2012; p. 145 - 159

Vanadium compounds are present in trace amounts in living organisms. In mammals, once absorbed from the gastrointestinal tract, they distribute among tissues and storage mainly in liver, kidney and bone. Vanadium compounds in pharmacological doses exert interesting effects as insulin enhancers, antitumoral and osteogenic agents. This review deals with the more relevant information about the osteogenic effects of vanadium compounds. Their actions on the different components of hard tissue and bone related cells in culture are summarized. Besides, the putative mechanism of action and the effects on in vivo models are also discussed