Synthesis, characterization and biological activity of vanadyl(IV) complexes with cyclic polyalcohols.

SUSANA B. ETCHEVERRY, DANIEL A. BARRIO, JUAN ZINCZUK, PATRICIA A.M. WILLIAMS, ENRIQUE J. BARAN

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Elsevier

Lugar: Amsterdam, Holanda; Año: 2005 vol. 99 p. 2322 - 2327

0949-8257

<!-- @page { size: 21cm 29.7cm; margin: 2cm } P { margin-bottom: 0.21cm } --> Oxovanadium (IV) complexes of the cyclic polyols conduritol C (cond) and myo-inositol (inos) of stoichiometry Na(2)[VO(cond)(2)].2H(2)O and Na(2)[VO(inos)(2)].H(2)O were obtained in aqueous alkaline solutions. They were characterized by infrared and UV-Vis spectroscopies, thermoanalytical (thermogravimetric and differential thermal analysis) data and magnetic susceptibility measurements. The biological activities of the complexes on the proliferation, differentiation and glucose consumption were tested on osteoblast-like cells in culture. Conduritol C and myo-inositol did not produce any effect on these parameters. Normal and tumoral cell proliferation was inhibited about (ca.40-60%) by the two oxovanadium (IV) complexes in concentrations as low as 100microM. The complexes were also inhibitory on cell differentiation (ca. 70-80%) while they stimulate glucose consumption. Comparisons of these effects with those of the oxovanadium (IV) cation, under the same experimental conditions, were also performed.