BHV-1 vaccine induces cross-protection against BHV-5 disease in cattle

DEL MEDICO; PUNTEL; ZAMORANO; SADIR; ROMERA

RESEARCH IN VETERINARY SCIENCE

ELSEVIER SCI LTD

Año: 2006 p. 327 - 334

0034-5288

Protection against BHV-5 disease induced by inactivated BHV-1 or BHV-5 based vaccines was analysed. Two groups of calves weresubcutaneously immunized with an inactivated BHV-1 or BHV-5 based vaccine. A third group was not vaccinated and used as control.In the post-vaccination period, we studied the humoral and cellular immune response resulting similar to both groups. The efficacy of thevaccines was tested after intranasal challenge of the calves with a virulent Argentinean BHV-5 isolate (A-663). All control animalsdeveloped neurological signs associated with BHV-5 infection and high levels of virus shedding. Calves immunized with the BHV-1and BHV-5 inactivated vaccines were protected against BHV-5 disease. Our study provides evidence that strongly support the existenceof cross-protection between BHV-1 and BHV-5 in calves. Even though this has already been suggested by previous works, this is the firsttime an exhaustive study of the immune response is performed and typical clinical BHV-5 meningoencephalitis signs are reproduced in anexperimental BHV-5 challenge trial. 2006 Elsevier Ltd. All rights reserved.