Maternal diets enriched in olive oil and safflower oil regulate pro-inflammatory pathways in metabolic organs in fetuses from diabetic rats

MARTÍNEZ, NORA; KURTZ, MELISA; CAPOBIANCO, EVANGELINA; JAWERBAUM, ALICIA

Iguassu

Congreso; V SLIMP Latin American Symposium on Maternal Fetal Interaction and Placenta.; 2013

PPARs are nuclear receptors involved in anti-inflammatory pathways which can be activated by unsaturated fatty acids that are present in olive (OL) and safflower (SAF) oils. AIM/METHODS: to analyze the effect of maternal diets enriched in 6% olive oil (OL) and 6% safflower oil (SAF) on nitric oxide (NO) production (nitrates/nitrites evaluation) and lipoperoxidation (TBARS evaluation) in the liver and heart from male (M) and female (F) term fetuses from control and diabetic rats. RESULTS: Maternal diabetes induces increases in NO production in the liver and heart from M and F fetuses, and in lipoperoxidation in M and F fetal livers and in M fetal hearts. Diets enriched in OL and SAF regulate fetal heart and fetal liver NO overproduction and lipoperoxidation in a gender- and organ-dependent manner. CONCLUSION: maternal diabetes induces fetal pro-inflammatory pathways, and dietary treatments enriched in PPAR ligands are capable of preventing these alterations.