INVESTIGADORES
GUERRIERI Diego
artículos
Título:
Evaluation of histological damage of solid organs after donor preconditioning with thymoglobulin in an experimental rat model.
Autor/es:
CICORA FEDERICO; STRINGA PABLO; GUERRIERI DIEGO; VAZQUEZ DANIELA; TONIOLO FERNANDA; ROBERTI JAVIER; RAIMONDI CLEMENTE
Revista:
TRANSPLANT IMMUNOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 28 p. 203 - 205
ISSN:
0966-3274
Resumen:
Rabbit anti-rat thymoglobulin (rATG) administered to donors with brain
death (BD) may improve organs quality. We explored the effects of rATG
administered to BD donors in the histology of heart, lungs and small
bowel in a rat experimental model. Animals were randomly assigned to 3
groups: V (n=5) no BD, 2h ventilation; BD (n=5) BD and 2h ventilation;
BD and rATG: BD, 2h ventilation, rATG (10mg/kg) after BD diagnosis.
Histopathological damage scores were based on neutrophil infiltration,
airway epithelial cell damage, interstitial edema, hyaline membrane
formation, and pulmonary hemorrhage (lungs); neutrophil infiltration and
interstitial edema (heart); Park score (bowel). Lung damage was
significantly lower in BD+rATG group: V 5 ± 1.6; BD 11.25 ± 0.5, BD+rATG
6.5 ± 1.9 (p<0.01). Heart: V 2.0 ± 0.81; BD 4.75 ± 1.25 and BD+rATG
3.5 ± 1.7 (p>0.05). Small bowel: BD 2.25 ± 0.96 vs. BD+rATG 1.00 ±
1.15 (n.s.). Histological damage amelioration in lung and attenuation
tendency in heart and small bowel encourages research of cytoprotective
strategies to improve organ viability.