INFLAMMATORY AGENTS INVOLVED IN SEPTIC MISCARRIAGE

JULIETA AISEMBERG; CLAUDIA VERCELLI; MANUEL WOLFSON; ANA INÉS SALAZAR; CLAUDIA OSYCKA SALUT; SILVIA BILLI; MARÍA LAURA RIBEIRO; MARIANA FARINA; ANA MARÍA FRANCHI

NEUROIMMUNOMODULATION.

Karger

Año: 2010 vol. 17 p. 150 - 152

1021-7401

Even though the understanding of the cause of early pregnancy loss due to chromosomal abnormalities has improved, there is a dearth of knowledge of the causes of loss in euploid conceptuses.Maternal infections are a cause of abort in humans but their mechanism are not clear, so we have developed a murine model to study the mechanism of septic abortion by inducing embryonic resorption (ER) with LPS.We demonstrated that nitric oxide (NO) and prostaglandins (PG) are involved in ER, observing augmented production of them and that inhibitors of their synthesis could prevent ER. Also, we observed an increase in the oxidative damage, evidenced by nitration of tyrosine proteins, due to the peroxynitrite anion.As it has been shown in women an association between chronic marijuana smoking and early miscarriage we studied the participation of anandamide (AEA), the principal endocannabinoid, in the mechanism of action of LPS. We showed that LPS-induced NO synthesis and tissue damage were mediated by AEA, and that this endotoxin inhibited AEA degradation and increased its synthesis.These results suggest that several inflammatory molecules participate in the mechanism of early pregnancy loss and that their modulation could be useful tools to prevent it.