Arsenic, diet and occupational exposure on prostate cancer risk in Córdoba, Argentina.

ROMÁN MARÍA DOLORES; MUÑOZ SONIA; NICLIS CAMILA; DÍAZ MARÍA DEL PILAR

Buenos Aires

Congreso; 5th International Congress on Arsenic in the Environment.; 2014

International Society of Groundwater for Sustainable Development

Introduction: Prostate cancer (PC) is the most incident cancer in Argentinian men. Lifestyle and environmental factors was related to PC risk.Objective: To evaluate the combined effect of arsenic, occupational exposure and dietary patterns on PC risk.Methods: A case-control study was conducted in Córdoba (2008-2013). Cases (n=138) were men with incident PC. Controls (n=288) were of identical age (±5 years) and place of residence than cases. All subjects were interviewed about sociodemographic characteristics, anthropometric variables, family history of cancer, lifestyle and dietary habits using a validated semistructured questionnaire. Arsenic content in samples of drinking water was determined. Factor analysis was performed to identify dietary patterns. An individual score for each pattern was calculated and used as covariate in risk analysis. A two level logistic regression model was fitted using PC status as the outcome. Age, occupational exposure (without-rural-industry), dietary patterns and arsenic in drinking water were included as covariates in level 1, and family history of PC as the variance component in level 2. Odds ratios (OR) and 95% confidence intervals (CI) were computed.Results: A high adherence to dietary pattern "Traditional" (red fat meat, eggs, nonstarchy vegetables and refined grains) and "Sweet Drinks" (soft drinks and juices) increases PC risk. Arsenic level higher than 10 µ/L, combined to occupational exposure to rural work, has a synergistic effect increasing PC risk (OR 3.55; 95%IC 1.59-7.94). Precision levels of OR increase when variability is captured within cancer family history of cancer categories (intraclass correlation 12.5%)Conclusions: High level of arsenic in drinking water and adhesion to unhealthy dietary patterns have an important role on PC risk. Also it is noteworthy the combined effect of arsenic coupled to occupational exposure in our population.