A catalyst-Free Synthesis of asymetric diaryl ketones from aryltims

G.F. SILBESTRI; R. BOGEL MASSON; M.T. LOCKHART; A.B. CHOPA

JOURNAL OF ORGANOMETALLIC CHEMISTRY

Estado Unidos

Lugar: Columbia; Año: 2006 p. 1520 - 1524

0022-328X

A series of diaryl ketones have been synthesized in good yields (40–78%) through the catalyst-free reaction of trimethylarylstannanes with aroyl chlorides in chlorobenzene as solvent. In addition, an attractive feature is that these reactions are completely regioselective making possible the synthesis of diarylketones which are not usually available under the influence of the directing forces of the substituents present in the aromatic ring. Also, the reaction conditions are mild enough to be applied to acid sensitive molecules.