INVESTIGADORES
SILBESTRI Gustavo Fabian
artículos
Título:
Ultrasound-assisted Synthesis of Benzophenones by Stille Cross-coupling Reactions. Optimization via Experimental Design
Autor/es:
M. LUONG; C.E. DOMINI; G.F. SILBESTRI; A.B. CHOPA
Revista:
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Editorial:
ELSEVIER SCIENCE SA
Referencias:
Lugar: Amsterdam; Año: 2013 p. 43 - 48
ISSN:
0022-328X
Resumen:
A series of diaryl ketones have been synthesized in moderate to excellent yields through the selective cross-coupling reaction of benzoyl chlorides with arylstannanes using a sonochemical variation of the Stille coupling. Ultrasound significantly enhances this useful organometallic transformation affording the desired products in higher yields and shorter reaction times than conventional reactions. The scope of the protocol has been explored with a selection of arylstannanes and different aroyl chlorides as reaction partners. Remarkably, no by-products resulting from homo-coupling could be detected. The ultrasoundpromoted cross-coupling reaction was optimized through experimental design.
