INVESTIGADORES
SILBESTRI Gustavo Fabian
artículos
Título:
Selective synthesis of mono- and distannylpyridines from chloropyridinols via an SRN1 Mechanism
Autor/es:
GUSTAVO F. SILBESTRI; MARCOS J. LO FIEGO; MAR[IA T. LOCKHART; ALICIA B. CHOPA
Revista:
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Editorial:
ELSEVIER SCIENCE SA
Referencias:
Año: 2010 vol. 695 p. 2578 - 2585
ISSN:
0022-328X
Resumen:
A selective two-step synthesis of either mono- or distannykated pyridines from commercially available pyridinols, involving its conversión to the corresponding diethyl pyridil phosphates (pyDEP) followed by the reaction with Me3SnNa in liquid ammonia, is described.
The results obtained cleary indicate that the reactions proceed through an unimolecular radical nucleophilic substitution mechanism (SRN1) with intermediacy of a monosubtitution product.
