Lipid droplets as ying-yang markers of neurodegeneration in models of synucleinopathies.

ALZA, N.P.; CONDE, M.; MANISCALCHI, A.; BENZI JUNCOS, O.N.; FUNK, M.I.; SALVADOR, G.

Congreso; Reunión Anual de Sociedades de Biociencias 2023; 2023

Alpha-synuclein (aSyn) pathology is a hallmark in the onset and progression of several synucleinopathies, including Parkinson’s disease. It has been demonstrated that lipid disturbances are associated with aSyn pathology. Our aim was to study neutral lipid metabolism in severalin vivo and in vitro models of aSyn accumulation. To this end, different forms of aSyn overexpressed in neurons and toxicant-induced animal models related with synucleinopathies were used. In neuronal cultures, we demonstrated that the overexpression of aSyn (WT and mutantA53T) induced the accumulation of lipid droplets (LD) and free cholesterol (p