INVESTIGADORES
STROBL MAZZULLA Pablo Hernan
artículos
Título:
Epithelial to mesenchymal transition: new and old insights from the classical neural crest model
Autor/es:
STROBL MAZZULLA, P.H.; BRONNER-FRASER, M.
Revista:
SEMINARS IN CANCER BIOLOGY
Editorial:
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 22 p. 411 - 416
ISSN:
1044-579X
Resumen:
The epithelial-to-mesenchymal transition (EMT) is an important event converting compact and ordered epithelial cells into migratory mesenchymal cells. Given the molecular and cellular similarities between pathological and developmental EMTs, studying this event during neural crest development offers and excellent in vivo model for understanding the mechanisms underlying this process. Here, we review new and old insight into neural crest EMT in search of commonalities with cancer progression that might aid in the design of specific therapeutic prevention.
