INVESTIGADORES
DE MIGUEL Natalia
artículos
Título:
Towards incorporating epigenetics into regulation of gene expression in the parasite Trichomonas vaginalis
Autor/es:
LIZARRAGA, AYELEN; MUĂ‘OZ, DANIELA; STROBL-MAZZULLA, PABLO.H.; MIGUEL, NATALIA
Revista:
MOLECULAR MICROBIOLOGY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2021
ISSN:
0950-382X
Resumen:
Trichomonas vaginalis is an extracellular parasite that colonizes the human urogenital tract, causing a highly prevalent sexually transmitted infection. The parasite must change its transcriptional profile in order to establish and maintain infection. However, few core regulatory elements and transcription factors have been identified to date and little is known about other mechanisms that may control these rapid changes in gene expression during parasite infection. In the last years, epigenetic mechanisms involved in the regulation of gene expression have been gaining major attention in this parasite. In this review, we summarize and discuss the major advances in the T. vaginalis field of the last few years with regard to epigenetics (DNA methylation, post‐translational histone modifications and histone variants). These studies can shed light into our current understanding of this parasite?s biology with far‐reaching implications for the prognosis and treatment of trichomoniasis.