INVESTIGADORES
MOTRICH Ruben Dario
artículos
Título:
Impact of vitamin D receptor activity on experimental autoimmune prostatitis
Autor/es:
MOTRICH RD; VAN ETTEN E; DEPOVERE J; RIERA CM; RIVERO VE; MATHIEU C
Revista:
JOURNAL OF AUTOIMMUNITY
Editorial:
Elsevier
Referencias:
Lugar: Davis; Año: 2009 vol. 32 p. 140 - 148
ISSN:
0896-8411
Resumen:
Chronic non bacterial prostatitis is a chronic inflammatory syndrome.
Its etiology and physiopathology are unclear and treatments are
empirical and ineffective in most cases. Autoimmunity has been proposed
as an etiology. In the present report, we investigated the impact of
vitamin D receptor silencing, by use of VDR-KO NOD mice and the
immune-modulating effect of the vitamin D3 analog TX527 on the
development of Experimental Autoimmune Prostatitis in NOD mice. VDR-KO
NOD mice developed a more aggressive form of autoimmune prostatitis
characterized by a greater lymphoproliferative response against
prostate antigen in vitro (6.92+/-4.77 vs. 2.47+/-0.41 21 days after
disease induction, p<0.05) and higher levels of specific INFgamma
secretion (471+/-6 vs. 386+/-5pg/ml, p<0.01). This was accompanied
in vivo by more severe lesions and augmented mononuclear cell
infiltration in the prostate gland. On the other hand, although
analog-treated mice showed a significant reduction in the spleen T-cell
specific proliferative response against prostate antigen in vitro, no
effect on disease development was observed. We conclude that vitamin D
receptor modulation holds the promise of interfering with autoimmune
prostatitis. Introduction of more powerful analogs, or combinations
with anti-T-cell reagents may represent therapeutic solutions for these
group of patients.