INVESTIGADORES
CASANAVE Emma Beatriz
artículos
Título:
Comparative Vertebrate Fibrinolysis
Autor/es:
TENTONI, J.; POLINI, N. N.; CASANAVE E.B.
Revista:
Comparative Clinical Pathology
Editorial:
Springer
Referencias:
Lugar: London; Año: 2010 vol. 19 p. 225 - 229
ISSN:
1618-5641
Resumen:
Fibrinolysis is a feature in the phylogeny of vertebrates. This review analyzes the fibrinolytic mechanism in different species compared to healthy adult humans. Additionally, it introduces the armadillo Chaetophractus villosus (Mammalia, Xenarthra, Dasypodidae) whose lytic process remains quite unknown until now. The analysis was conducted in a phylogenetic order: fish, amphibians, reptiles, birds and mammals. It was designed to assess the fibrinolytic system in its various stages: global, specific and degradation. The results are represented in tables grouped by test: Fibrinogen; Whole blood lysis time; Whole blood diluted lysis time; Euglobulin lysis time; Plasminogen; Fibrin fibrinogen degradation products; D Dimer; Plasminogen activator inhibitor type 1 and alpha 2 antiplasmin activity. Global knowledge of the mechanism of fibrinolysis in vertebrates is a contribution of scientific interest not only in biology, but also for the development of experimental models applicable to the study of thrombotic and thrombolytic agents.
