Urban Air Pollution Induces Oxidative Stress, Inflammation And Mitochondrial Disfunction In Mice Brain Cortex And Olfactory bulb.

CALABRO, VALERIA; GARCÉS, MARIANA; MARCHINI, TIMOTEO; MAGNANI, NATALIA; CACERES, LOURDES; FREIRE, AGUSTINA; VICO, TAMARA; VANASCO, VIRGINIA; BERDASCO, CLARA; DIODATI MENDEZ, NAHUEL; MARTINEFSKI, MANUELA; BUCHHOLZ, BRUNO; TRIPODI, VALERIA; GOLDSTEIN, JORGE; GELPI, RICARDO; BERRA, ALEJANDRO; ALVAREZ, SILVIA; EVELSON, PABLO

Congreso virtual

Congreso; 27th Annual Conference of the Society for Redox Biology and Medicine; 2020

Society for Redox Biology and Medicine

Previous reports indicate that the central nervous system (CNS) is a target of air pollution, causing tissue damage and functional alterations. Oxidative stress and neuroinflammation have been point out as possible mechanisms mediating these effects. The aim of this work was to study the chronic effects of urban air pollution on mice brain cortex (CX) and olfactory bulb (OB), focusing on oxidative and inflammatory markers, and mitochondrial function. Male 8-week-old BALB/c mice were exposed to filtered air (FA, control) or urban air (UA) inside whole-body inhalation chambers located in a highly polluted area of Buenos Aires City, for up to 4 weeks. Glutathione levels, assessed as GSH/GSSG ratio, were decreased in CX after 1 and 2 w of exposure to UA, and after 4 w in the case of the OB (26% and 60% respectively; p