Time course of lung inflammation and cardiac oxygen metabolism in a mice model of continuous exposure to urban air pollution

MARCHINI, TIMOTEO; GARCÉS, MARIANA; CALABRO, VALERIA; PAZ, MARIELA; LAGO, NESTOR; CACERES, LOURDES; VICO, TAMARA; GUAGLIANONE, ALEJANDRO; VANASCO, VIRGINIA; GONZALEZ MAGLIO, DANIEL; BERRA, ALEJANDRO; ALVAREZ, SILVIA; EVELSON, PABLO

Ciudad de Buenos Aires

Congreso; LXII Reunión Científica Anual; 2017

Sociedad Argentina de Investigación Clínica

The exposure to air pollution leads to increased morbidity and mortality rates from cardiorespiratory diseases. In has been suggested that local and systemic oxidative stress and inflammation play a central role in this scenario. The aim of this work was to characterize a mice model of continuous exposure to urban air pollution, by the assessment of different markers of pulmonary, systemic, and cardiac oxygen metabolism and inflammation. 8-week-old balb/c male mice were exposed to urban or filtered air (control) inside a chamber located in a highly populated area of Buenos Aires City. Animals were exposed for 8 h/day, 5 days/week, for up to 3 months. After 2 months, mice exposed to urban air pollution showed a 53% increase in total leucocytes in bronchoalveolar lavage (BAL) samples in comparison with the control group (control: 1.0±0.2 x105 cells, p