The exposure to a transition metal-rich environmental particulate matter surrogate induces acute inflammatory leukocyte recruitment by boosting endothelial and myeloid cell activation

MARCHINI, TIMOTEO; ANTO MICHEL, NATHALY; TASAT, DEBORAH; WOLF, DENNIS; BODE, CHRISTOPH; EVELSON, PABLO; ZIRLIK, ANDREAS

Chascomus

Congreso; IV Latin American Meeting on Biological Inorganic Chemistry; 2014

LABIC2014

The present findings indicate that an acute exposure to environmental PM triggers a systemic inflammatory response characterized by the up-regulation of adhesion molecules in EC and myeloid cells. This effect is induced by pro-inflammatory cytokines and, at least in part, transition metals present as PM constituents. As a consequence of PM exposure, macrophage activation and cytokine release might drive the systemic inflammatory response leading to PM-associated adverse cardiovascular effects.