Mitochondrial function is impaired in the primary visual cortex in an experimental glaucoma model

HVOZDA ARANA, AILEN G.; LASAGNI VITAR, ROMINA M.; REIDES, CLAUDIA G.; CALABRÓ, VALERIA; MARCHINI, TIMOTEO; LERNER, S. FABIÁN; EVELSON, PABLO A.; FERREIRA, SANDRA M.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ELSEVIER SCIENCE INC

Año: 2021

0003-9861

Glaucoma is a neurodegenerative disease that affects eye structures and brain areas related to the visual system. Oxidative stress plays a key role in the development and progression of the disease. The aims of the present study were to evaluate the mitochondrial function and its participation in the brain redox metabolism in an experimental glaucoma model.3-month-old female Wistar rats were subjected to cauterization of two episcleral veins of the left eye to elevate the intraocular pressure. Seven days after surgery, animals were sacrificed, the brain was carefully removed and the primary visual cortex was dissected. Mitochondrial bioenergetics and ROS production, and the antioxidant enzyme defenses from both mitochondrial and cytosolic fractions were evaluated.When compared to control, glaucoma decreased mitochondrial ATP production (23%, p