Developments in plant-based vaccines against diseases of concern in developing countries

EVANGELINA GÓMEZ, SILVINA CHIMENO ZOTH, ANALÍA BERINSTEIN

The Open Infectious Diseases Journal.

Bentham Science Publishers

Año: 2010 vol. 4 p. 55 - 62

1874-2793

<!-- /* Font Definitions */ @font-face {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4; mso-font-charset:0; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:-1610611985 1073750139 0 0 159 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin-top:0cm; margin-right:0cm; margin-bottom:10.0pt; margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:Calibri; mso-fareast-font-family:Calibri; mso-bidi-font-family:"Times New Roman"; mso-ansi-language:ES-AR; mso-fareast-language:EN-US;} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> Vaccines are one of the great successes of modern medicine. However, the development and implementation of new vaccines remains prohibitively expensive for economically depressed countries where such measures are needed most. Plant-produced vaccines provide a promising new strategy that combines the innovations in genomics, medicine, and plant biotechnology to create affordable biological products. In the past decade, a growing number of research groups worldwide have studied plant expression and oral delivery of vaccine antigens, some showing very promising potential. Here, we describe the basis of the system and the state of the art of developments regarding diseases of concern in developing countries.