Potential use of the hemagglutinini-neuraminidase glycoprotein of Newcastle Disease Virus expressed in Rachiplusia nu larvae as an immunogen for chickens

SILVINA CHIMENO ZOTH, EVANGELINA GÓMEZ, J. MANUEL CARBALLEDA, OSCAR TABOGA, ELISA CARRILLO AND ANALÍA BERINSTEIN

CLINICAL AND VACCINE IMMUNOLOGY

AMER SOC MICROBIOLOGY

Año: 2009 vol. 16 p. 775 - 778

1556-6811

<!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} p.composio, li.composio, div.composio {mso-style-name:composição; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; mso-bidi-font-size:10.0pt; font-family:"Courier New"; mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman"; mso-ansi-language:EN-US; mso-fareast-language:PT-BR;} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> The hemagglutinin-neuraminidase (HN) glycoprotein of Newcastle disease virus (NDV) was obtained as a recombinant antigen in Rachiplusia nu larvae. When used as immunogen in chickens, a solid immune response, including neutralizing antibodies, was detected, demonstrating the potential use of this simple and economic strategy in the design of recombinant anti-NDV vaccines.