INVESTIGADORES
CHIMENO ZOTH Silvina Andrea
artículos
Título:
Infectious BursalDiseaseVirus non-structural protein VP5 is not a transmembrane protein
Autor/es:
CARBALLEDA JUAN MANUEL; MARONICHE GUILLERMO; LUCERO MARIA SOLEDAD; RICHETTA MATÍAS; EVANGELINA GOMEZ; CHIMENO ZOTH SILVINA; ANALIA BERINSTEIN
Revista:
VIROLOGY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 2015 vol. 483 p. 312 - 317
ISSN:
0042-6822
Resumen:
Infectious BursalDiseaseVirus(IBDV)causesahighlyrelevantpoultrydiseasethataffectsyoungchickens causing,amongothereffects,immunosuppression.IBDVisabi-segmenteddoublestrandedRNAvirus.ThesmallerORFoflargerRNAsegmentencodesVP5,a17-kDanon-structuralprotein.Although itisanimportantproteinforviralreplicationcycle,thedefinition ofitsspecific roleandsubcellular localizationremainsunclear.In thepresentworkwedemonstrate,usingimagingtechniques,thatVP5isnotatypeIItransmembraneproteinbutanintracellularmembrane-associatedprotein.This finding mightprovideevidences ofVP5interactionwithcellularproteinsanditsfunctions.
