Further characterization of chicken´s immune response to Newcastle Disease Virus Conventional Vaccines: Locally produced mucosal IgG

S. CHIMENO ZOTH; E. GÓMEZ; E. CARRILLO; A. BERINSTEIN

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Facultad de Medicina de Ribeirao Preto

Lugar: Ribeirao Preto, SP, Brasil; Año: 2007

0100-879X

Newcastle disease virus (NDV) is the causative agent of an economically important disease which afects all species of birds worldwide. Current vaccination programs for NDV include the use of either low-virulent live-virus vaccines or inactivated vaccines to induce protective immunity while producing minimal adverse effects in birds. With the purpose of further characterize the immune response elicited by live virus and inactivated NDV conventional vaccines in chickens, the presence of specific antibodies in different secretions and in tissue culture supernatants of immunized birds was evaluated. We found specific anti-NDV IgG antibodies in tracheal and cloacal swabs and tracheal and intestinal washes of immunized animals. We also found specific anti-NDV IgG antibodies in tracheal and intestinal tissue culture supernatants, indicating that the IgG found in swabs and washes was not transudated from serum or, at least, was not all transudated from serum. Knowledge about the mechanisms involved in the immune response of chickens to different NDV vaccines might increase our understanding of the mucosal response against the virus and, eventually, supply new information useful for the development and evaluation of synthetic vaccines.