Galectins differentially regulate the release of platelet-derived angiogenic molecules.

SCHATTNER M; ETULAIN J; NEGROTTO S; ROMANIUK MA; CROCI DO; CATTANEO V; CAMPETELLA O; RABINOVICH GA

Kyoto

Congreso; XXIII Congress of the International Society on Thrombosis and Haemostasis 2011.; 2011

We have recently demonstrated that galectin (Gal)-1 and -8 trigger platelet activation. Since these lectins also promote angiogenesis and platelets contribute to the formation of new vessels by releasing angiogenic mediators in a local fashion, here we examined the release of angiogenesis mediators from platelets stimulated with Gal-1 or -8. The levels of angiogenic molecules in the supernatants were determined by ELISA after stimulation of human washed platelets for 5 min. Results are expressed in ng/ml (*p