INVESTIGADORES
SCHATTNER Mirta Ana
artículos
Título:
Platelet TLR4 at the crossroads of thrombosis and the innate immune response
Autor/es:
SCHATTNER, MIRTA
Revista:
JOURNAL OF LEUKOCYTE BIOLOGY
Editorial:
FEDERATION AMER SOC EXP BIOL
Referencias:
Año: 2018 vol. 105 p. 873 - 880
ISSN:
0741-5400
Resumen:
Platelet TLR-4 activation by pathogen- or damage-associated molecular pattern molecules triggers pro-thrombotic, proinflammatory, and pro-coagulant effector responses. Moreover, platelet TLR4 has a prominent role as a sensor of high lipopolysaccharide circulating levels during sepsis and in the clearance of pathogens mediated by neutrophils. This review presents evidence pointing to TLR4 as a bridge connecting thrombosis and innate immunity.
