INVESTIGADORES
SCHATTNER Mirta Ana
artículos
Título:
Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic or non-pathogenic Junín virus strains
Autor/es:
NEGROTTO S; MENA HA; URE AE; JAQUENOD DE GIUSTI C; BOLLATI-FOGOLÍN M; VERMEULEN EM; SCHATTNER M; GOMEZ RM
Revista:
JOURNAL OF VIROLOGY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Lugar: Washington; Año: 2015 vol. 89
ISSN:
0022-538X
Resumen:
The Junín virus (JUNV) arenavirus is the etiologic agent of Argentina Haemorrhagic Fever (AHF). We characterised the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection by the C#1 strain (attenuated), and even more, by the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expressions after infection with both JUNV strains.
