The influence of sex and different segments of the thoracic aorta on bioactive aortic substance (BAS) and prostacyclin (PGI2) synthesis

MAUGERI N; BERMEJO E; FALETTI A; SCHATTNER M; CHAUD MA; GIMENO MF; LAZZARI MA

THROMBOSIS RESEARCH

Año: 1989 vol. 56 p. 19 - 27

0049-3848

BAS is a protein generated by aortic rings isolated from rats. Our previous results clearly established that BAS inhibits platelet aggregation and modifies vascular tone. We have now examined the effect of separated segments of thoracic aorta and the effect of sex on the release of the BAS and PGI2. We evaluated three different segments of thoracic aorta: A = aortic arch, B = the upper segment and C = the lowest segment of the thoracic aorta. We measured the release of BAS and PGI2 from them. The BAS production increased in the first segment (A) when compared with the other two (B and C), whilst PGI2 production was the same along the thoracic aorta. On the other hand female and male thoracic aorta produced the same levels of BAS and 6-keto PGF1 cm.