Interferon-gamma enhances PAF-acether production by stimulated human polymorphonuclear

JORGE R. GEFFNER; MIRTA SCHATTNER; MARIA A. LAZZARI; MARTIN A. ISTURIZ

SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Año: 1991 vol. 33 p. 575 - 578

0300-9475

Human polymorphonuclear leucocytes (PMN) stimulated with either immune complexes (IC), phorbol myristate acetate (PMA) or N-formyl-methionyl-leucyl-phenylalanine (FMLP) generate platelet-activating factor (PAF-acether). The present study demonstrates that treatment of PMN with recombinant human interferon-gamma (IFN-gamma) significantly enhanced the production of PAF-acether by stimulated cells, in a concentration-dependent mode. On the contrary, alpha and beta IFN were completely unable to increase PAF-acether synthesis by stimulated PMN. The significance of these results is discussed.