INVESTIGADORES
RADIVOY Gabriel Eduardo
congresos y reuniones científicas
Título:
Unsupported copper nanoparticles in the 1,3-dipolar cycloaddition of terminal alkynes and azides
Autor/es:
F. ALONSO; Y. MOGLIE; G. RADIVOY; M. YUS
Lugar:
Alicante, España
Reunión:
Congreso; 6th Eurasian Meeting on Heterocyclic Chemistry (6th EAMHC); 2010
Institución organizadora:
Universidad de Alicante, Departamento de Química Orgánica
Resumen:
The synthesis of 1,2,3-triazoles, based on the 1,3-dipolar cycloaddition of organic azides and alkynes, catalyzed by unsupported copper nanoparticles is presented. Reactions were performed at 65ºC, in THF as solvent and in the presence of Et3N as base. The corresponding triazoles were obtained in good to excellent yields. The copper nanoparticles were in situ generated and exhibited superior catalytic activity when compared with other commercially available copper sources. A reaction mechanism has been postulated in which copper(I) acetylides appear as the true intermediate species.