Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole Moiety

E. BJERG; J. MARCHÁN GARCÍA; G. RADIVOY; Y. MOGLIE; E. BUXADERAS

Basilea

Congreso; 26th ECSOC; 2022

MDPI

A series of new 1,2,3-triazolylphosphonates were synthesized through the multicomponent alkyne-azide 1,3-dipolar cycloaddition catalyzed by copper nanoparticles on activated carbon. The reactions were carried out in water and at a very low copper loading as green conditions, leading to the triazolylphosphonate products in moderate to good yields. Studies about their activity as butyrylcholinesterase inhibitors are underway.