INVESTIGADORES
MONTEJANO Hernan Alfredo
congresos y reuniones científicas
Título:
Model of drugs release from 2-hydroxyethylmethacrylate / acrylamide hydrogels synthesized by photopolymerization: Influence of the ionic character of THE drugs.
Autor/es:
GÓMEZ, M.L; R. J. J. WILLIAMS; H. A. MONTEJANO; C. M. PREVITALI
Lugar:
La Serena
Reunión:
Congreso; X Encuentro Latinoamericano de Fotoquímica y Fotobiología (XELAFOT); 2010
Institución organizadora:
ELAFOT
Resumen:
In this work we report the synthesis of hydrogels employing visible-light photopolymerization. A silsesquioxane functionalized with methacrylate and amine groups (SFMA) was employed as crosslinker/co-initiator to obtain hydrogels, based on 2-hydroxyethylmethacrylate (HEMA) and acrylamide (AAm); safranine O (Saf) was employed as sensitizer. These hydrogels were loaded with different model drugs; the influence of the ionic character of a specific drug on its release rate from the hydrogel was analyzed. The following ionic or uncharged dyes were employed to mimic drugs: acridine orange (AO) as a neutral drug, Saf as a cationic drug, and resorufin (Rf) as an anionic drug. The release rates of the dyes were investigated by UV-Vis spectroscopy.
