Towards biomedical application of amino-functionalized silicon nanoparticles

LILLO, CRISTIAN; CALIENNI, M. NATALIA; GOROJOD, ROXANA; RIVAS AIELLO, M. BELÉN; RODRÍGUEZ SARTORI, DAMIÁN; PRIETO, MARÍA JIMENA; ALONSO, SILVIA DEL VALLE; KOTLER, MÓNICA; GONZÁLEZ, MÓNICA; MONTANARI, JORGE

NANOMEDICINE

FUTURE MEDICINE LTD

Lugar: Londres; Año: 2018 vol. 13 p. 1349 - 1370

1743-5889

Background: Silicon blue-emitting nanoparticles are promising effectors for photodynamic therapy and radiotherapy, because of their production of reactive oxygen species (ROS) upon irradiation. Results: Amino-functionalized silicon nanoparticles (NH2SiNP) were intrinsically non-toxic below 100 µg/ml in vitro (on two tumor cell lines) and in vivo (zebrafish larvae and embryos). NH2SiNP showed a moderate effect as a photosensitizer for PDT and reduced ROS generation in radiotherapy, which could be indicative of a ROS scavenging effect. Encapsulation of NH2SiNP into ultradeformable liposomes improved their skin penetration after topical application, reaching the viable epidermis where neoplastic events occur. Conclusion: subsequent derivatizations after amino-functionalization and incorporation to nano-drug delivery systems could expand the spectrum of the biomedical application of these kind of silicon nanoparticles