Nanoberries: cómo transportar antioxidantes a través de la piel para protegerla de la radiación UV

BUCCI, PAULA L; CALIENNI, M. NATALIA; ALONSO, S. DEL VALLE; MONTANARI, JORGE

Revista Cosmetica

Asociación Argentina de Químicos cosméticos

Lugar: Buenos Aires; Año: 2015 vol. 89

0326-7385

SUMMARY: Nanoberries are an ultradeformable liposome formulation of an ethanolic extract from bluberry (Vaccinium myrtillus), rich in antioxidants, mainly anthocyanins and other polyphenolic compounds. Liposomes are obtained by resuspension of a phosopholipid solution in which solvent was previously removed by evaporation. They have a mean size under 120 nm after undergoing sonication, and they carry the extract in their inner aqueous space. The addition of a border activator to the phospholipid solution confers ultradeformability to the formulation, allowing the liposomes to change their shape without losing structure, at room temperature. Such a feature makes them specially useful for the topical way, as they can penetrate the stratum corneum instead of act only as a reservoir in the outer surface of the skin. This would allow to take profit of the antioxidant capacity of the encapsulated polyphenols for blocking the action of free radicals, origined by exposure to enviromental UV sunlight. In this work we explain a new method for their preparation and we present preliminar results on cutaneous penetration. We also explore their potential application as a cosmetic formulation for protecting skin damage.