Synthesis, structure and SOD activity of Mn complexes with symmetric Schiff base ligands derived from pyridoxal

SIGNORELLA, S. R.; DAIER, V.; LEDESMA, G.N.; PALOPOLI, C.; BACK, D. F.; SCHULZ LANG, E.; EBANI, P.; PEREIRA, M.B. ; GIACOMELLI, C.; PIQUINI, P.C.

POLYHEDRON

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2015 vol. 102 p. 176 - 184

0277-5387

This study describes the synthesis, crystal structure and antioxidant activity of manganese(III) complexes with Schiff-base ligands obtained from condensation of pyridoxal with alkyl diamines: [Mn(pyr2en) (H2O)2]Cl 4H2O, [Mn(pyr2en)(H2O)(CH3OH)]Cl, [Mn(pyr2pn)(H2O)2]ClO4 and [Mn2(pyr2bn)3] 4H2O, where H2pyr2en = 1,2-bis(pyridoxylidenamino)ethane, H2pyr2pn = 1,3-bis(pyridoxylidenamino)propane and H2pyr2bn = 1,4-bis(pyridoxylidenamino)butane. The four complexes catalyze the dismutation of superoxide efficiently with IC50 values in the range of 1.22-2.15 lM, evaluated through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The length of the alkyl spacer in the diamine fragment plays a key role in the antioxidant activity of these complexes, with [Mn(pyr2pn)(H2O)2]ClO4 showing the lowest IC50 value.