Cytotoxic terpenoids from Nardophyllum bryoides

MARIANELA SÁNCHEZ, MARCIA MAZZUCA, MARÍA JOSÉ VELOSO, LUCÍA R. FERNÁNDEZ, GASTÓN SILESS, LYDIA PURICELLI, JORGE A. PALERMO

PHYTOCHEMISTRY

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2010 vol. 71 p. 1395 - 1399

0031-9422

The investigation of the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoidescollected in the province of Chubut, Argentina, yielded eleven terpenoids. These include: three secoent-halimane diterpenoids (1–3), two ent-halimanes (4–5) and six pentacyclic oleanane and ursane triterpenoids(6–11). Four of these compounds (2, 6, 8 and 11) are hitherto unknown, while two others (1and 4) have been previously reported but only as synthetic products. Several of these compounds showedmoderate cytotoxicity against a human pancreatic adenocarcinoma cell line while compounds 4 and 5were active at micromolar concentrations. The main component, seco-chiliolidic acid (1), could be isolatedfrom this extract in large amounts, turning N. bryoides into a sustainable source of this bioactivecompound.