DENDRITIC THERMORESPONSIVE NANOGELS AS VERSATILE PLATFORMS FOR BIOMEDICAL APPLICATIONS

M.A. MOLINA; CALDERÓN, MARCELO

Simposio; VII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE NANOMEDICINA (NANOMEDAR); 2016

Nanogels are nanosizedcrosslinked networks composed of hydrophilic or amphiphilic polymer chains. They are developed as carriers to transport small molecules such as drugs, dyes, or biomacromolecules. Thermoresponsive polymers undergo a phase transition at a certain temperature in aqueous media. As a Consequence,they can change their aggregation state, exhibit conformational change and undergo shrinking, swelling, or micellization upon a thermaltrigger. The combination of nanogel properties and thermoresponsiveness Represents a promising approach for the development of smart nanocarrier systems, which reveals high loading capacity, improves drug stability, and thus can be used for stimuli-controlled release in drug delivery. Herein, the engineering of thermoresponsive dendritic nanogels using different thermoresponsive polymers and synthetic methodologies for biomedical applications is presented.