SEMI INTERPENETRATED DENDRITIC THERMORESPONSIVE NANOGELS FOR BIOMEDICAL APPLICATIONS

MARIA MOLINA; STEFANIE WEDEPOHL; MARCELO CALDERON

Simposio; XII SIMPOSIO ARGENTINO DE POLÍMEROS; 2017

Nanogels (NGs) are nanosized crosslinked networks composed of hydrophilic or amphiphilic polymer chains.They are developed as carriers to transport small molecules such as drugs, dyes, or biomacromolecules [1].The combination of NG properties and thermoresponsiveness represents a promising approach for thedevelopment of smart nanocarrier systems [2,3]. Moreover, nanocomposites based on the semiinterpenetration of thermoresponsive NGs open a new window to a wide range of materials to be applied innanomedicine [4]. Herein, the engineering of semi interpenetrated thermoresponsive dendritic NGs based onpoly N-isopropylacrylamide (PNIPAM) is presented to be used for biomedical applications. We havesynthesized a thermoresponsive NG which is semi interpenetrated (s-IPN) with a conductive polymer,polyaniline (PANI), that generates heat after being irradiated by NIR radiation, inducing a localhyperthermia to be use in photothermal therapy [5]. Furthermore, based in the same synthetic methodologywe have synthesized a thermoresponsive NG which is s-IPN with a charged polymer, which expose its chargeson demand upon a temperature triggered. DOXO, an anti-cancer drug was encapsulated and efficientlytriggered release after an increase in the temperature media. More importantly, DOXO-loaded NGs haveproven to efficiently overcome the resistance of cells in vivo [6].